Muscle Growth & Repair Peptides

This category includes peptides that enhance muscle development, accelerate recovery, and promote repair of soft tissues such as tendons and ligaments. They work through different pathways: stimulating growth hormone release, activating repair mechanisms, boosting mitochondrial function, and reducing inflammation. Below is an overview of the main peptides in this group:

 

• Kisspeptin-10

  is a short peptide fragment of the kisspeptin hormone that stimulates the hypothalamic–pituitary–gonadal (HPG) axis, which is the main hormonal pathway controlling testosterone production.

Mechanism

1. 1. Hypothalamus
      Kisspeptin-10 binds to GPR54 (KISS1R) receptors on GnRH neurons in the hypothalamus. This triggers pulsatile release of gonadotropin-releasing hormone (GnRH).

   2. Pituitary
      GnRH acts on the anterior pituitary, causing secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). The effect is dose-dependent and relies on pulsatile GnRH signaling.

   3. Testes
      LH stimulates Leydig cells to produce testosterone from cholesterol via the usual steroidogenic pathway. FSH supports spermatogenesis. The result is an increase in circulating testosterone levels without introducing exogenous androgens.

Pharmacology

• • Kisspeptin-10 is rapidly acting with a short half-life (minutes).

  • It does not directly increase testosterone; its effect is upstream through GnRH and LH stimulation.

  • In men, a single subcutaneous or intravenous dose increases LH and testosterone within 30–60 minutes.

  • Repeated or continuous exposure can blunt the effect due to receptor desensitization.

Key Points

• • Kisspeptin-10 activates the natural axis rather than replacing hormones.

  • Effectiveness depends on a functional hypothalamus and pituitary.

  • It is being investigated as a potential alternative to GnRH analogues or clomiphene for stimulating endogenous testosterone.

• BPC-157
  A fragment of body protection compound, BPC-157 is well known for tissue healing. It supports tendon and ligament repair, accelerates muscle recovery, and reduces inflammation at injury sites.

• TB-500 (Thymosin Beta-4)
  TB-500 promotes angiogenesis (new blood vessel formation), cell migration, and tissue regeneration. Often paired with BPC-157, it enhances healing speed and recovery from muscle and connective tissue injuries.

• CJC-1295
  A growth hormone–releasing hormone (GHRH) analog that boosts growth hormone (GH) and IGF-1 secretion. By elevating these anabolic hormones, CJC-1295 supports muscle hypertrophy, fat metabolism, and repair.

• Ipamorelin
  A growth hormone secretagogue that stimulates GH release without raising cortisol or prolactin. When stacked with CJC-1295, Ipamorelin creates a synergistic effect, amplifying muscle growth and recovery benefits.

• IGF-1 LR3
  An extended version of insulin-like growth factor-1, IGF-1 LR3 promotes muscle protein synthesis and hyperplasia (growth in the number of muscle fibers). It plays a central role in increasing lean muscle and accelerating recovery.

• MOTS-c
  A mitochondrial-derived peptide that activates AMPK, improving cellular energy use, fat oxidation, and exercise capacity. It protects against fatigue and enhances training efficiency, indirectly supporting muscle growth and repair.

• Tesamorelin
  A GHRH analog that increases GH and IGF-1 levels. It promotes muscle anabolism, reduces visceral fat, and supports tissue regeneration. Tesamorelin is clinically recognized for improving body composition.

Together, these are some of the peptides that form a comprehensive toolkit for athletes and individuals seeking improved muscle growth, faster recovery, and better resilience to training stress and injuries.